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Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence

Provvidenza M Abruzzo1, Silvia Canaider1,2, Valeria Pizzuti1

  • 1Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.

Stem Cells International
|October 26, 2020
PubMed

Insights

Cellular senescence, a key aging factor, drives age-related diseases. This review explores herb-derived products as potential treatments to combat senescent stem cells and improve cell therapy.

Area of Science:

  • Gerontology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular senescence is a significant contributor to organismal aging and age-related diseases (ARDs).
  • Aging impairs stem cell (SC) self-renewal and function, leading to senescent SC accumulation.
  • The senescence-associated secretory phenotype (SASP) characterizes cellular senescence.

Purpose of the Study:

  • To review herb-derived products as novel interventions for cellular senescence.
  • To evaluate the efficacy of these natural agents in preventing or counteracting SC senescence.
  • To explore potential applications in cell therapy using pretreated multipotent mesenchymal stromal cells (MSCs).

Main Methods:

  • Literature review of studies investigating natural compounds for anti-senescence effects.
  • Analysis of research on the efficacy of herb-derived products in preventing or reversing SC senescence.
  • Examination of data on the application of these agents in preclinical and clinical models.

Main Results:

  • Several herb-derived products show promise in preventing or counteracting cellular senescence.
  • These natural agents may mitigate the negative effects of senescence on stem cells.
  • The precise mechanisms of action for many of these compounds require further elucidation.

Conclusions:

  • Herb-derived products represent a promising avenue for therapeutic strategies against aging and ARDs.
  • Further research is needed to fully understand and harness the potential of these natural compounds for cell senescence treatment.
  • Targeting senescent stem cells with natural agents could enhance cell therapy efficacy.

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