Related Experiment Video

Updated: Dec 4, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Published on: May 27, 2011

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Antivirals for COVID-19 in Solid Organ Transplant Recipients

Justin C Laracy1, Elizabeth C Verna2, Marcus R Pereira1

  • 1Department of Medicine, Division of Infectious Disease, Columbia University College of Physicians & Surgeons, 622 W 168th St PH 876 W, New York, NY 10032 USA.

Current Transplantation Reports
|October 26, 2020
PubMed
Abstract

Insights

Current evidence supports remdesivir for severe COVID-19 patients. More research is needed, especially for solid organ transplant recipients, on effective antiviral therapies.

Area of Science:

  • Infectious Diseases
  • Virology
  • Pharmacology

Background:

  • The COVID-19 pandemic necessitated rapid development of antiviral therapies.
  • Limited data exists on the efficacy of these treatments, particularly in immunocompromised populations.

Purpose of the Study:

  • To critically evaluate published studies on promising antiviral therapies for COVID-19.
  • To identify any solid organ transplant (SOT)-specific information regarding these treatments.

Main Methods:

  • Systematic review of critical studies on COVID-19 antiviral therapies.
  • Focused search for SOT recipient-specific data.

Main Results:

  • Most clinical trials for COVID-19 antivirals are preliminary, lacking robust evidence.
  • Remdesivir is an exception, with trials supporting its use in severe COVID-19.
  • No SOT-specific data on remdesivir or other antivirals has been published.

Conclusions:

  • Current evidence supports remdesivir for severe COVID-19 cases.
  • Further studies are urgently required, especially for SOT recipients.
  • Robust evidence for other antiviral therapies is currently lacking.
Keywords:
COVID-19Convalescent plasmaRemdesivirSARS-CoV-2Solid organ transplant

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