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Related Experiment Videos

Is there a calcification factor common to all calcifying matrices?

E Bonucci1

  • 1Department of Human Biopathology, La Sapienza University, Rome, Italy.

Scanning Microscopy
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

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Crystal ghosts, organic molecules templating inorganic structures, may be the common factor in early calcification. Their composition, potentially including alkaline phosphatase, facilitates calcium and phosphate binding.

Area of Science:

  • Biomineralization
  • Biochemistry
  • Cell Biology

Background:

  • Calcification is a complex biological process involving specific structures.
  • Understanding the early stages of calcification is crucial for various physiological and pathological conditions.

Purpose of the Study:

  • To review morphological findings in early calcification.
  • To identify a potential common calcification factor across different matrices.

Main Methods:

  • Morphological analysis of calcifying tissues.
  • Literature review of existing data on collagen fibrils, matrix vesicles, and crystal ghosts.

Main Results:

  • Crystal ghosts are the only structures found in all calcified tissues.

Related Experiment Videos

  • Crystal ghosts act as organic templates for inorganic structures.
  • Crystal ghosts, potentially containing alkaline phosphatase, bind calcium and phosphate ions.

    • Conclusions:

    • Crystal ghosts are proposed as a common calcification factor.
    • Early calcification initiation involves ion binding to crystal ghosts.
    • Crystal ghosts share properties with crystal-bound proteins.