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Updated: Dec 4, 2025

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CKS1B as Drug Resistance-Inducing Gene-A Potential Target to Improve Cancer Therapy

Wenwen Shi1, Qiudi Huang1, Jiacui Xie1

  • 1Key Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Frontiers in Oncology
|October 26, 2020
PubMed

Insights

Targeted cancer therapy is advancing, with Cyclin-dependent kinase regulatory subunit 1B (CKS1B) emerging as a key target. Understanding CKS1B

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cancer treatment is shifting towards precision targeted therapy.
  • Targeted therapy selectively eliminates cancer cells, minimizing harm to healthy tissues.
  • Identifying novel therapeutic targets is crucial for effective cancer treatment.

Purpose of the Study:

  • To review the cellular functions and mechanisms of Cyclin-dependent kinase regulatory subunit 1B (CKS1B).
  • To summarize recent research on CKS1B as a target for cancer therapy.
  • To discuss the therapeutic potential of CKS1B in treating human cancers.

Main Methods:

  • Literature review of CKS1B's role in cell cycling and cancer.
  • Analysis of studies investigating CKS1B as a therapeutic target.
  • Discussion of CKS1B's association with cancer pathogenesis and drug resistance.

Main Results:

  • CKS1B is integral to cell cycle regulation.
  • CKS1B is implicated in the development and progression of numerous human cancers.
  • CKS1B is linked to cancer drug resistance.

Conclusions:

  • CKS1B plays a significant role in cancer.
  • CKS1B presents a promising therapeutic target for precision cancer treatment.
  • Further research into CKS1B mechanisms can advance targeted cancer therapies.
Keywords:
CKS1Bcell cyclingdrug resistancehuman cancerstherapeutic target

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