Post-stroke BDNF concentration changes following proprioceptive neuromuscular facilitation (PNF) exercises

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Biochemistry

Background:

• Brain-derived neurotrophic factor (BDNF) is crucial for brain repair, with physical exercise potentially enhancing its release.
• Acute stroke significantly impacts BDNF levels, affecting brain function and recovery.

Purpose of the Study:

• To evaluate the effect of Proprioceptive Neuromuscular Facilitation (PNF) on BDNF levels and functional recovery in acute stroke patients.
• To compare BDNF levels and functional outcomes before and after PNF intervention.

Main Methods:

• 208 first-time stroke patients were assessed for stroke severity, type, cognitive function (MMSE), functional independence (FIM), and BDNF levels.
• BDNF levels were measured pre- and post-PNF intervention, with healthy individuals serving as controls.

Main Results:

• Stroke patients exhibited significantly lower BDNF levels, with further decline correlating with stroke severity.
• Patients with risk factors like diabetes and hypertension showed specific BDNF level ranges.
• PNF exercise led to significant improvements in both BDNF levels and FIM scores across all stroke types and risk factor profiles.

Conclusions:

• Proprioceptive neuromuscular facilitation (PNF) is an effective intervention for enhancing functional recovery in acute stroke.
• PNF improves BDNF levels and functional outcomes irrespective of stroke type or patient risk factors.