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Using rodent models to understand interactions between gambling and substance use.

Barry Setlow1,2,3,4, Shelby L Blaes1,2, Matthew R Burns5

  • 1Department of Psychiatry, University of Florida, Gainesville, FL, 32610, USA.

Current Opinion in Behavioral Sciences
|October 26, 2020
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Summary

This review highlights how rodent models reveal causal links between substance use and gambling behavior. Findings show predisposing factors, drug exposure, and gambling experience influencing each other, aiding future research.

Keywords:
Gamblingaddictionratsrisk takingrodentssubstance use

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Area of Science:

  • Neuroscience and Behavioral Science
  • Addiction Research
  • Animal Models in Psychology

Background:

  • Substance use and gambling disorder frequently co-occur, but their causal relationship is complex.
  • Understanding the interplay between these behaviors is crucial for developing effective treatments.
  • Rodent models provide a controlled environment to investigate the underlying mechanisms of co-occurring substance use and gambling.

Purpose of the Study:

  • To review recent rodent research examining the bidirectional relationship between substance use and gambling-like behaviors.
  • To identify predisposing factors and consequences of co-exposure to drugs of abuse and gambling stimuli in animal models.
  • To explore the utility of rodent models for dissecting the neurobiological underpinnings of comorbid addiction.

Main Methods:

  • Review of existing literature on rodent studies investigating substance use and gambling.
  • Analysis of research examining factors that predispose individuals to both behaviors.
  • Examination of studies where drug exposure influences gambling behavior and vice versa.
  • Inclusion of research on comorbid gambling and substance use in the context of Parkinson's disease therapies.

Main Results:

  • Identified predisposing factors common to both substance use and gambling-like behaviors in rodents.
  • Demonstrated that exposure to drugs of abuse can enhance gambling-like behavior in animal models.
  • Showed that engaging in gambling-like behavior can increase subsequent substance use in rodents.
  • Highlighted the association between gambling-like behavior and substance use in rodent models relevant to Parkinson's disease treatments.

Conclusions:

  • Rodent models are valuable tools for understanding the causal relationships between substance use and gambling.
  • Findings suggest a complex, bidirectional influence between these two behavioral disorders.
  • This research opens avenues for novel therapeutic strategies targeting comorbid substance use and gambling disorders.