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Hyperthyroidism and hepatic dysfunction: Report of 17 cases
Benothman Wafa1, Hadjkacem Faten1, Elleuch Mouna1
1Department of Endocrinology Hedi Chaker Hospital Sfax Tunisia.
JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|October 26, 2020
Summary
Hyperthyroidism frequently causes liver dysfunction, from mild to severe, affecting cholestasis and hepatocellular injury. Restoring thyroid function normalizes liver tests, highlighting the need to check thyroid status in unexplained liver abnormalities.
Area of Science:
- Endocrinology
- Hepatology
- Internal Medicine
Background:
- Hyperthyroidism is associated with abnormal liver chemistry.
- Hepatic dysfunction is a recognized complication of thyroid disorders.
Purpose of the Study:
- To describe the clinical, biochemical, and therapeutic features of hepatic dysfunction in hyperthyroidism.
- To investigate the relationship between thyroid dysfunction and liver injury.
Main Methods:
- Retrospective study of 17 patients with untreated hyperthyroidism and hepatic dysfunction.
- Exclusion of patients with pre-existing liver disease.
- Analysis of clinical data, liver function tests, and thyroid hormone levels.
Main Results:
- Most patients had Graves' disease; 11 had congestive heart failure.
- Hepatic dysfunction ranged from moderate to severe, with cholestasis and hepatocellular injury observed.
- Thyroid peroxidase antibodies correlated with bilirubin; ALT correlated with left ventricular ejection fraction.
Conclusions:
- Liver injury in hyperthyroidism is common and can be severe.
- Evaluating thyroid function is crucial for patients with unexplained hepatic abnormalities.
- Restoring euthyroidism leads to normalization of liver function tests.
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