Related Experiment Video

Updated: Dec 3, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.2K

Calcification Biomarkers, Subclinical Vascular Disease, and Mortality Among Multiethnic Dialysis Patients

Jessica Fitzpatrick1, Esther D Kim2,3, Stephen M Sozio3,4

  • 1Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

Kidney International Reports
|October 26, 2020
PubMed

Insights

Circulating calcification biomarkers like OPG and FGF23 are modestly linked to cardiovascular disease in hemodialysis patients, but not mortality. Further research in diverse populations is needed.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomarker Research

Background:

  • Vascular calcification and stiffness are linked to poor outcomes in hemodialysis patients.
  • Mechanisms and biomarker associations remain unclear, with conflicting prior studies.
  • This study investigates novel calcification biomarkers in incident dialysis patients.

Purpose of the Study:

  • To determine associations between circulating calcification biomarkers and cardiovascular disease.
  • To examine relationships with vascular calcification, stiffness, and mortality.
  • To investigate fibroblast growth factor 23 (FGF23), dp-ucMGP, fetuin-A, and osteoprotegerin (OPG) in hemodialysis.

Main Methods:

  • Cross-sectional analysis of 391 incident hemodialysis participants from the PACE study.
  • Assessed baseline FGF23, dp-ucMGP, fetuin-A, and OPG.
  • Correlated biomarkers with coronary artery calcium (CAC) score, pulse wave velocity (PWV), and all-cause mortality.

Main Results:

  • Higher OPG and FGF23 associated with increased coronary artery calcium prevalence.
  • OPG linked to higher baseline PWV; FGF23 linked to lower PWV over time.
  • dp-ucMGP and fetuin-A showed no association with CAC or PWV.
  • No circulating biomarkers were associated with mortality after adjustment.

Conclusions:

  • Circulating calcification biomarkers show modest associations with subclinical cardiovascular disease in hemodialysis.
  • No biomarkers were significantly associated with mortality in this cohort.
  • Further validation in larger, diverse hemodialysis populations is warranted.
Abstract

Keywords:
arterial stiffnessfetuin Afibroblast growth factor 23hemodialysismatrix Gla proteinosteoprotegerin

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.0K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.9K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
389
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
247
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
231
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
383
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
493
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
170