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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Related Experiment Video

Updated: Dec 3, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Advances in biomarker development and potential application for preeclampsia based on pathogenesis.

Nan Liu1,2, Yu-Na Guo3, Li-Kun Gong1,2

  • 1School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.

European Journal of Obstetrics & Gynecology and Reproductive Biology: X
|October 26, 2020
PubMed
Summary

Preeclampsia (PE) is a serious pregnancy complication lacking effective treatments. Combining maternal risk factors and validated biomarkers shows promise for early prediction and intervention, improving maternal and infant health.

Keywords:
BiomarkerHypothesisPredictPreeclampsia

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Biomarker Research

Background:

  • Preeclampsia (PE) is a pregnancy-specific condition with unknown etiology and no effective treatments.
  • PE poses significant risks to maternal and infant health, forcing difficult decisions regarding pregnancy management.
  • Current recommendations suggest combining maternal risk factors with biomarkers for PE prediction.

Purpose of the Study:

  • To review and classify potential biomarkers for preeclampsia based on major etiological hypotheses.
  • To discuss the underlying mechanisms of biomarkers in PE pathogenesis.
  • To advocate for the combined use of multiple biomarkers for improved PE risk prediction and clinical intervention.

Main Methods:

  • Systematic review of clinical research data on potential preeclampsia biomarkers.
  • Classification of biomarkers according to four major hypotheses: placental ischemia/hypoxia, vascular injury, oxidative stress, and immune dysregulation.
  • Discussion of biomarker involvement in PE pathogenesis.

Main Results:

  • Identified and categorized numerous potential biomarkers implicated in PE.
  • Highlighted the roles of placental factors, endothelial dysfunction, oxidative stress, and immune responses in PE development.
  • Emphasized the need for validated biomarkers for clinical application.

Conclusions:

  • A combination of multiple biomarkers reflecting diverse pathogenic aspects is crucial for accurate PE risk prediction.
  • Validated biomarkers can facilitate targeted interventions and prevention strategies for high-risk populations.
  • Future research focusing on sensitive and reliable biomarkers holds the potential to significantly improve PE detection accuracy.