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Related Experiment Video

Updated: Dec 3, 2025

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Growth arrest-specific 2 protein family: Structure and function.

Nan Zhang1,2, Chunyan Zhao1,2, Xinxin Zhang1,2

  • 1Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Cell Proliferation
|October 26, 2020
PubMed
Summary

The growth arrest-specific 2 (GAS2) protein family, including GAS2, GAS2L1, GAS2L2, and GAS2L3, plays roles in cell functions. This review details their structures and functions in processes like cell cycle and cancer.

Keywords:
GAS2GAS2L1GAS2L2GAS2L3cell cyclecytoskeleton

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The growth arrest-specific 2 (GAS2) protein family comprises four members: GAS2, GAS2L1, GAS2L2, and GAS2L3.
  • These proteins possess actin-binding (CH) and microtubule-binding (GAR) domains, functioning as smaller versions of spectraplakins.

Purpose of the Study:

  • To systematically review the expression patterns, interaction characteristics, and roles in biological issues of the GAS2 family members.
  • To provide a comprehensive molecular understanding of the GAS2 family's involvement in diverse cellular processes.

Main Methods:

  • Literature review and synthesis of existing evidence on GAS2 family members.
  • Analysis of structural and functional data from various studies.

Main Results:

  • Significant differences exist among GAS2 family members regarding expression, interactions, and involvement in diseases.
  • GAS2 family proteins are implicated in cytoskeleton reorganization, cell cycle regulation, apoptosis, and cancer development.

Conclusions:

  • A comprehensive understanding of GAS2 family members' structures and functions is crucial.
  • This review consolidates knowledge on the GAS2 family's multifaceted roles in fundamental biological processes and disease pathology.