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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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[APNEA OF PREMATURITY - PATHOPHYSIOLOGY, TREATMENT & PROGNOSIS]

Alex Gileles-Hillel1,2, Ira Erlichman3, Joel Reiter1

  • 1Pediatric Pulmonology and Sleep Unit, Hadassah University Hospital and The Hebrew University Medical School.

Harefuah
|October 26, 2020
PubMed

Insights

Apnea of prematurity, common in preterm infants, can lead to serious complications. This review covers its causes, treatment, and care after neonatal intensive care unit discharge.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology

Background:

  • Apnea of prematurity affects most infants born before 34 weeks gestation.
  • Recurrent apnea is linked to mortality and neurodevelopmental issues.

Purpose of the Study:

  • To review advances in understanding apnea of prematurity.
  • To address clinical questions for healthcare providers.
  • To discuss post-discharge care and recommendations.

Main Methods:

  • Literature review of recent advances.
  • Synthesis of clinical information.
  • Discussion of monitoring and discharge protocols.

Main Results:

  • Updated understanding of pathophysiology.
  • Guidance on clinical management.
  • Recommendations for neonatal intensive care unit discharge and follow-up.

Conclusions:

  • Effective management of apnea of prematurity is crucial.
  • Continued research and updated guidelines are essential for improving outcomes.
Abstract

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