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Idiopathic Pericardial Ossification Causing Chronic Constrictive Pericarditis.

Sandhya Biswal¹, Rudra Pratap Mahapatra², Anirban Kundu¹

¹AIIMS Bhubaneswar, Pathology and Lab Medicine, Bhubaneswar, India.

Fetal and Pediatric Pathology

|October 26, 2020

Summary

This summary is machine-generated.

Idiopathic pericardial ossification can lead to chronic constrictive pericarditis (CCP) in children. This case study highlights ossification and hematopoiesis in a pediatric pericardiectomy specimen, ruling out infection or tumors.

Keywords:

Chronic constrictive pericarditis ossification pediatric pericardium

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Area of Science:

Cardiology
Pathology
Pediatric Medicine

Background:

Chronic constrictive pericarditis (CCP) results from pericardial fibroinflammation, with diverse causes like tuberculosis, trauma, surgery, radiation, and malignancy.
The pericardium, a sac enclosing the heart, can undergo pathological changes leading to restrictive filling of the cardiac chambers.

Observation:

A pericardiectomy specimen from a 17-year-old boy with CCP was analyzed.
Histopathological examination revealed significant pericardial ossification, characterized by bone remodeling and hematopoietic activity within marrow spaces.

Findings:

The pericardial ossification demonstrated mature bone formation and active hematopoiesis.
No evidence of granulomatous inflammation or neoplastic processes was found, suggesting an idiopathic etiology.

Implications:

Idiopathic pericardial ossification is a potential cause of CCP in pediatric patients.
This finding expands the differential diagnosis for constrictive pericarditis in children, emphasizing the need to consider ossification even without typical etiological factors.