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Updated: Dec 3, 2025

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Fumonisin-containing diets decrease the metabolic activity of myenteric neurons in rats.

Fernando Carlos Sousa¹, Christiano Rodrigues Schamber², Eneri Vieira de Souza Leite Mello²

¹Department of Biology, Federal University of Technology - Paraná; Dois Vizinhos, Paraná, Brazil.

Nutritional Neuroscience

|October 26, 2020

Summary

This summary is machine-generated.

Fumonisins, mycotoxins in food, reduce metabolic activity in rat enteric neurons and brain mitochondria. This neurotoxic effect impacts the nervous system

Keywords:

NADH-diaphorase NADPH-diaphorase fumonisins mitochondrial dysfunction myenteric plexus neuroplasticity neurotoxicity

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Area of Science:

Toxicology
Neuroscience
Food Safety

Background:

Fumonisins are mycotoxins contaminating food, posing risks to human and animal health.
Their neurotoxic effects are known, but the precise mechanisms remain unclear.

Purpose of the Study:

To investigate the neurotoxic mechanisms of fumonisins on the rat nervous system.
To assess the impact of fumonisin exposure on neuronal metabolism and mitochondrial function.

Main Methods:

Male Wistar rats were fed diets containing fumonisins B1+B2 (0, 1, 4 mg/kg).
Morphoquantitative analyses of myenteric neurons (NADH- and NADPH-diaphorase activity) were performed.
Mitochondrial respiratory metabolism in brain and liver was assessed.

Main Results:

Fumonisins did not significantly alter food consumption, body weight, or plasma parameters.
Exposure decreased metabolic activity and neuronal density in jejunal myenteric neurons.
Cell body area of nitrergic neurons and mitochondrial oxygen consumption in brain and liver were reduced.

Conclusions:

Fumonisins impair the metabolic activity of enteric neurons and mitochondrial respiratory function.
These effects suggest a mechanism for fumonisin-induced neurotoxicity impacting the enteric nervous system's neuroplasticity.