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Size-Transformable Nanostructures: From Design to Biomedical Applications.

Xiaodong Zhang1,2,3, Xiaokai Chen4, Jun Song2

  • 1International Joint Research Center for Molecular Science, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China.

Advanced Materials (Deerfield Beach, Fla.)
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

Choosing nanostructures (NSs) for disease theranostics is challenging due to size-dependent properties. Size-transformable NSs offer a solution by combining the benefits of small and large NSs for improved theranostic applications.

Keywords:
bacterial infectioncancer treatmentsmart nanomedicinestructural transformationtheranostics

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Nanostructure (NS) size critically influences chemical, physical, and biological properties.
  • Both small and large NSs have distinct advantages for disease theranostics, creating a selection paradox.
  • Size-transformable NSs present a novel approach to harness the benefits of multiple size regimes.

Purpose of the Study:

  • To review strategies for constructing size-transformable nanostructures.
  • To highlight recent advancements in their biomedical applications, focusing on theranostics.
  • To inspire further development of size-transformable NSs for diverse applications.

Main Methods:

  • Literature review of synthesis strategies for size-transformable nanostructures.
  • Analysis of recent research on biomedical applications, particularly in cancer and bacterial theranostics.
  • Synthesis and characterization of size-transformable nanostructures (if applicable, otherwise omit).

Main Results:

  • Various construction strategies for size-transformable NSs have been identified.
  • Significant progress has been made in applying these NSs to cancer and bacterial theranostics.
  • Size-transformable NSs demonstrate potential for overcoming limitations of fixed-size nanostructures.

Conclusions:

  • Size-transformable nanostructures offer a versatile platform for advanced theranostic applications.
  • Further research into novel construction methods and applications is warranted.
  • These adaptable nanostructures hold promise for future innovations in medicine and beyond.