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Related Experiment Video

Updated: Dec 3, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
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Organ-Level Functional 3D Tissue Constructs with Complex Compartments and their Preclinical Applications.

Jaeseo Lee1,2, DoYeun Park1,3, Yoojin Seo1,4

  • 1KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)
|October 26, 2020
PubMed
Summary

Advancements in 3D tissue constructs are creating more complex, organ-level models for preclinical research. These sophisticated tissue engineering strategies aim to improve in vitro and in vivo applications for life-saving biomedical tools.

Keywords:
neural compartmentsorgan-level functional 3D tissuespreclinical applicationsscale up engineered tissuevascular compartments

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Increasing interest in organ-level 3D tissue constructs due to their in vivo-like features.
  • Sophisticated technologies like organoid generation, microfluidics, hydrogel engineering, and 3D printing enhance 3D tissue construct complexity.
  • Focus on vascularized and innervated 3D tissue constructs to mimic the interconnected nature of human physiology.

Purpose of the Study:

  • To categorize strategies for scaling up 3D tissue constructs based on material dimensionality (0D-3D).
  • To highlight novel approaches for increasing complexity in 3D tissue constructs.
  • To investigate recent advances in preclinical applications and future directions for 3D tissue construct research.

Main Methods:

  • Categorization of scaling-up strategies by material dimensions (0D, 1D, 2D, 3D).
  • Review of novel approaches for enhancing 3D tissue construct complexity.
  • Investigation of recent preclinical applications of advanced 3D tissue constructs.

Main Results:

  • Strategies for creating complex 3D tissue constructs are presented and categorized.
  • Novel methods for incorporating vascular and neural systems into 3D constructs are highlighted.
  • Recent preclinical applications demonstrate the potential of advanced 3D tissue models.

Conclusions:

  • Overcoming challenges in developing organ-level functional 3D tissue constructs is crucial.
  • Advanced 3D tissue constructs hold significant promise for preclinical research and biomedical applications.
  • Continued innovation in tissue engineering will lead to life-saving tools in the biomedical field.