Related Experiment Video
Updated: Dec 3, 2025
08:46
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
15.9K
A Biological Age Model Designed for Health Promotion Interventions: Protocol for an Interdisciplinary Study for Model
Karina Louise Skov Husted1,2, Mathilde Fogelstrøm1, Pernille Hulst1
1Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
JMIR Research Protocols
|October 26, 2020
Summary
This study develops a biological age model to assess health and disease risk in aging populations. The model aims to provide a more accurate measure of health span than chronological age alone.
Area of Science:
- Gerontology and Longevity Research
- Biomarker Discovery and Validation
- Preventive Medicine and Public Health
Background:
- Growing global aging population necessitates strategies for healthy aging and morbidity delay.
- Biological age estimation offers a personalized health metric beyond chronological age.
- Understanding lifestyle's impact on health span is crucial for public health initiatives.
Purpose of the Study:
- To develop an interdisciplinary biological age model.
- To explore the clinical utility and applications of the developed biological age model.
Main Methods:
- A cross-sectional study derived candidate biomarkers from 100 healthy aging individuals.
- Principal component analysis was employed for biological age estimation.
- A validation cohort of overweight adults in a lifestyle intervention will test the model's clinical use.
Main Results:
- Data collection and initial analysis of the cross-sectional study are complete.
- Principal component analysis results are available; model interpretation and refinement are ongoing.
- Recruitment for the validation cohort is pending; results are anticipated by December 2021.
Conclusions:
- The biological age model is expected to serve as a valuable indicator of disease and metabolic risk.
- Further large-scale validation studies are recommended to confirm the model's efficacy.
- Biological age assessment can empower individuals and healthcare providers in promoting health span.
Related Concept Videos
01:18Models of Health Promotion and Illness Prevention II
1.9K
The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
The agent-host-environment model states that disease results...
1.9K
01:25Models of Health Promotion and Illness Prevention I
2.5K
A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
2.5K
01:26Aging
469
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
469
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
187
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
187
02:20Longitudinal Research
12.9K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.9K
01:19The Effect of Aging on Tissues
3.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K