Related Experiment Video
Updated: Dec 3, 2025
12:31
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
15.5K
Photo-switching of blunt-end stacking between DNA strands immobilized on gold nanoparticles
Naoki Kanayama1, Satomi Kishi, Tohru Takarada
1Bioengineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. nkanayama@riken.jp.
Chemical Communications (Cambridge, England)
|October 26, 2020
Abstract:
End-to-end intermolecular interaction between double-stranded DNAs grafted onto individual nanoparticles is regulated by terminal base pairing/unpairing triggered by the photo-isomerization of an azobenzene moiety inserted in the vicinity of the DNA terminal. This is the first example of highly reversible control of blunt-end stacking under both isothermal and isoionic-strength conditions.
