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Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis.

Myrte Strik1, Declan T Chard2, Iris Dekker3

  • 1Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands/Department of Radiology and Medicine, The University of Melbourne, Melbourne, VIC, Australia.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

Physical disability in multiple sclerosis (MS) is linked to increased sensorimotor network efficiency and connectivity, particularly in the primary somatosensory cortex (S1). This occurs independently of structural brain damage.

Keywords:
Multiple sclerosisdisabilityefficiencyfunctional MRInetworkresting-state

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Physical disability in multiple sclerosis (MS) is not fully understood.
  • Network abnormalities may underlie MS-related physical disability.

Purpose of the Study:

  • Investigate changes in functional network efficiency within the sensorimotor system in MS patients.
  • Explore the relationship between functional network efficiency and disability levels in MS.

Main Methods:

  • Compared functional connectivity and efficiency in 222 MS patients (low vs. high disability) and 82 healthy controls.
  • Utilized general linear models and binary logistic regression to analyze sensorimotor network efficiency (LE) and its association with disability.
  • Assessed functional connectivity patterns in 23 sensorimotor regions.

Main Results:

  • High disability (HD) MS patients showed higher local efficiency (LE) in the left primary somatosensory cortex (S1) and right pallidum compared to low disability (LD) and healthy controls (HC).
  • Left premotor cortex LE was also higher in HD patients versus HC.
  • A logistic regression model identified age, deep grey matter volume, and left S1 LE as predictors of disability status (R²=0.38).
  • HD patients exhibited increased S1 functional connectivity with prefrontal and secondary sensory areas.

Conclusions:

  • Clinical disability in MS is associated with increased functional sensorimotor network efficiency and connectivity.
  • These changes are centered around the primary somatosensory cortex (S1).
  • The observed functional network alterations are independent of structural brain damage.