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Global Reports of Intussusception in Infants With SARS-CoV-2 Infection

Jennifer E Giovanni1, Susan Hrapcak, Michael Melgar

  • 1From the COVID-19 Response Team, U.S. Centers for Disease Control and Prevention.

The Pediatric Infectious Disease Journal
|October 26, 2020
PubMed

Insights

Five infants with confirmed SARS-CoV-2 infection developed intussusception, a bowel obstruction. While not definitively linked, this suggests COVID-19 testing for infants with intussusception symptoms may be warranted.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Idiopathic intussusception is a common cause of bowel obstruction in infants.
  • Coronavirus disease 2019 (COVID-19) symptoms in children can include gastrointestinal issues.
  • The presentation of COVID-19 in infants is not well characterized.

Purpose of the Study:

  • To investigate a potential association between SARS-CoV-2 infection and intussusception in infants.
  • To describe the clinical characteristics of infants with intussusception and confirmed SARS-CoV-2 infection.

Main Methods:

  • Retrospective case series of 5 infants diagnosed with intussusception between January and July 2020.
  • Laboratory confirmation of SARS-CoV-2 infection in all reported cases.
  • Clinical data review including symptoms, presentation, and outcomes.

Main Results:

  • Five infants (4-10 months) with laboratory-confirmed SARS-CoV-2 infection presented with intussusception.
  • All infants exhibited currant jelly stool and at least one other abdominal symptom; none had respiratory symptoms.
  • Four infants recovered; one infant experienced critical illness and died.

Conclusions:

  • A potential association between SARS-CoV-2 infection and intussusception in infants is suggested.
  • Infants presenting with intussusception symptoms may warrant SARS-CoV-2 testing, particularly with known exposure or COVID-19 symptoms.
  • Further research is needed to establish causality and understand if intussusception is part of the COVID-19 clinical spectrum in infants.

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