Related Experiment Video
Updated: Dec 3, 2025
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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
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Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review
Jesper Bonde1, Fabio Bottari, Anna D Iacobone
1Molecular Pathology Laboratory, Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark.
Journal of Lower Genital Tract Disease
|October 26, 2020
Summary
Same-genotype persistence (SGTP) of human papillomavirus (HPV) is a stronger indicator of high-grade cervical intraepithelial neoplasia (CIN) than genotype switching. SGTP improves risk assessment for CIN compared to standard HPV testing.
Area of Science:
- Gynecology
- Oncology
- Infectious Diseases
Background:
- Cervical intraepithelial neoplasia (CIN) is a precancerous condition.
- Human papillomavirus (HPV) infection is the primary cause of CIN.
- Distinguishing HPV infection dynamics is crucial for accurate risk stratification.
Purpose of the Study:
- To compare the association of HPV same-genotype persistence (SGTP) versus genotype switch (GS) with high-grade CIN.
- To evaluate HPV clearance and new infection as predictors of high-grade CIN.
- To assess the clinical utility of genotype-specific HPV testing for CIN risk.
Main Methods:
- Systematic review and meta-analysis of prospective and retrospective studies.
- Inclusion of studies with extended- or full-genotype HPV reporting.
- Primary outcome: high-grade CIN after at least two testing rounds.
Main Results:
- Continued HPV-positive women were divided into SGTP and GS groups.
- SGTP demonstrated significantly higher sensitivity, positive predictive value, and positive likelihood ratio than GS.
- HPV genotypes can be tiered based on CIN risk and persistence.
Conclusions:
- Moderately high-quality evidence supports SGTP's clinical utility.
- SGTP improves risk discrimination for high-grade CIN compared to qualitative HPV testing.
- Genotype-specific HPV information enhances CIN management.
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