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Related Experiment Videos

Reflections on reentry and focal activity.

M J Janse1, C N D'Alnoncourt

  • 1Department of Cardiology and Experimental Cardiology, University of Amsterdam, The Netherlands.

The American Journal of Cardiology
|October 16, 1987
PubMed
Summary
This summary is machine-generated.

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Reentrant arrhythmias like ventricular tachycardia during myocardial ischemia can be prevented by agents prolonging the wavelength. Lidocaine and moricizine HCl show effectiveness in preventing ventricular fibrillation and suppressing abnormal automaticity, respectively.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Myocardial Ischemia Research

Background:

  • Reentrant arrhythmias, including ventricular tachycardia and fibrillation, are critical in acute myocardial ischemia.
  • Mechanisms of reentry involve circus movement, with or without anatomic obstacles.

Purpose of the Study:

  • To discuss the mechanisms of reentrant arrhythmias during acute myocardial ischemia.
  • To emphasize the role of wavelength in maintaining reentry.
  • To evaluate agents that prevent reentry by altering wavelength or suppressing premature beats.

Main Methods:

  • Discussion of circus movement reentry and the concept of wavelength (refractory period x conduction velocity).
  • Experimental models using isolated pig hearts and papillary muscle preparations.

Related Experiment Videos

  • Administration of lidocaine before coronary artery occlusion and moricizine HCl on partially depolarized papillary muscle.

    • Main Results:

    • Myocardial tissue mass must exceed wavelength for circus movement tachycardia maintenance.
    • Multiple reentrant wavelets are required for fibrillation.
    • Lidocaine prevented ventricular fibrillation in pig hearts.
    • Moricizine HCl suppressed abnormal automaticity in papillary muscle.

    Conclusions:

    • Agents prolonging wavelength can prevent reentry.
    • Lidocaine is effective against ventricular fibrillation during ischemia.
    • Focal mechanisms like abnormal automaticity can initiate arrhythmias, and agents suppressing them are beneficial.