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Updated: Dec 3, 2025

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
[Role of skin immunity on wound healing]
1State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China.
Abstract:
The immune system of skin is consisted of different types of immune cells which distribute in epidermis and dermis. By adjusting the microenvironment of wound, these immune cells regulate the migration, proliferation, differentiation and other functions of epidermal cells, endothelial cells, and fibroblasts, thus taking part in re-epithelialization and formation of granulation tissue and having great influences on wound healing in the end. Acknowledging the interaction of these cells and identifying the targets that regulate the functions of immune cells will provide direction for improving the speed and quality of wound healing.
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