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[Structure of SARS-CoV-2 and treatment of COVID-19]

Hai-Xia Chen1, Zhi-Hua Chen1, Hua-Hao Shen2

  • 1Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|October 27, 2020
PubMed

Insights

This review details the structure of SARS-CoV-2, the virus causing COVID-19, and explores potential pharmaceutical treatments for the disease. It examines the virus

Area of Science:

  • Virology
  • Infectious Diseases
  • Pulmonology

Background:

  • COVID-19, caused by SARS-CoV-2, is a novel coronavirus pneumonia impacting global health.
  • The virus targets lung cells via ACE2, leading to inflammation and respiratory distress.
  • Severe cases can trigger cytokine storms and systemic inflammatory response syndrome.

Purpose of the Study:

  • To review the structural characteristics of SARS-CoV-2.
  • To summarize current pharmaceutical treatments for COVID-19.
  • To explore potential links between viral structure and treatment efficacy.

Main Methods:

  • Literature review of scientific articles on SARS-CoV-2 structure.
  • Analysis of published data on COVID-19 pharmaceutical interventions.
  • Synthesis of information regarding structure-activity relationships in treatments.

Main Results:

  • SARS-CoV-2 possesses a specific structure crucial for cell entry and infectivity.
  • Various pharmaceutical agents are being investigated and utilized for COVID-19 treatment.
  • Understanding viral structure may guide the development of more effective therapies.

Conclusions:

  • The structure of SARS-CoV-2 is a key factor in its pathogenesis.
  • Pharmaceutical treatments aim to inhibit viral replication or mitigate host response.
  • Further research into structure-based drug design holds promise for future COVID-19 therapies.

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