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Related Experiment Video

Updated: Dec 3, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Medication errors and risk areas in a critical care unit.

Juan Escrivá Gracia1, Álvaro Aparisi Sanz2, Ricardo Brage Serrano1

  • 1Nursing Department, University of Valencia, Valencia, Spain.

Journal of Advanced Nursing
|October 27, 2020
PubMed
Summary

Medication errors in critical care are frequent, often originating during prescription. Nurse transcription acts as a crucial filter, preventing many errors from reaching patients, though specific areas like antibiotic timing and nasogastric administration remain high-risk.

Keywords:
drug interactionsmedication errorsnursing in critical carepharmacoepidemiology

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Area of Science:

  • Critical Care Medicine
  • Patient Safety
  • Pharmacology

Background:

  • Medication errors pose a significant threat to patient safety in critical care settings.
  • Identifying the sources and patterns of these errors is crucial for developing effective interventions.

Purpose of the Study:

  • To identify prevalent medication errors in critical care.
  • To determine the causality and contributing factors of these errors.
  • To pinpoint the highest-risk areas for medication errors.

Main Methods:

  • A descriptive, longitudinal, and retrospective study design was employed.
  • Systematic analysis of 2,634 medication dose units across prescription, transcription, and administration records.
  • Data collected from 87 critically ill patients treated in 2018.

Main Results:

  • The prescription phase exhibited the highest error rate (71%) and was the primary cause of errors (68%).
  • Significant drug interactions were frequently observed.
  • Key risk areas included antibiotic administration timing, dilution errors, medication concentration, administration speed of high-risk drugs, and nasogastric tube administration techniques.

Conclusions:

  • A substantial number of medication errors persist in critical care, with many originating from prescription-stage issues.
  • Nurse transcription serves as a vital intervention point, mitigating a considerable number of potential errors.
  • Specific interventions are needed for time-dependent antibiotics, high-risk medications, and nasogastric tube administration to enhance patient safety.