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Published on: August 12, 2019
Synthetic Factors Governing Access to Tris(β-diketimine) Cyclophanes versus Tripodal Tri-β-aminoenones
Mary C Eaton1, Brian J Knight1, Robin Brahmi1
1Center for Catalysis and Florida Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, 214 Leigh Hall, P.O. Box 117200, Gainesville, Florida 32611, United States.
Abstract:
Tris(β-diketimine) cyclophanes are an important ligand class for investigating cooperative multimetallic interactions of bioinorganic clusters. Discussed herein are the synthetic factors governing access to tris(β-diketimine) cyclophanes versus tripodal tri-β-aminoenones. Cyclophanes bearing Me, Et, and MeO cap substituents and β-Me, Et, or Ph arm substituents are obtained, and a modified condensation method produced α-Me β-Me cyclophane. These operationally simple procedures produce the ligands in gram quantities and in 22-94% yields.
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