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Captopril-related (and -induced?) asthma.

V Popa1

  • 1Veterans Administration Outpatient Clinic, University of California at Davis, Sacramento 95823.

The American Review of Respiratory Disease
|October 1, 1987
PubMed
Summary

Captopril, a blood pressure medication, can trigger asthma attacks in some individuals. This rare drug-induced asthma highlights the role of angiotensin-converting enzyme in airway function.

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Area of Science:

  • Pharmacology
  • Pulmonology
  • Allergology

Background:

  • Hypertension management often involves multiple medications.
  • Angiotensin-converting enzyme (ACE) inhibitors are commonly prescribed for hypertension.

Observation:

  • A 51-year-old male, with no prior respiratory or allergic history, developed asthma symptoms after initiating captopril therapy.
  • The patient was concurrently treated with nadolol and dyazide for hypertension.

Findings:

  • A double-blind challenge demonstrated a significant decrease in forced expiratory volume in 1 second (FEV1) with captopril (12%) compared to nadolol (3%).
  • This confirmed captopril as the causative agent for the patient's asthma attacks.

Implications:

  • This case underscores the potential for ACE inhibitors like captopril to induce asthma, a rare but significant adverse effect.
  • Understanding the role of ACE in bronchomotor mediator metabolism is crucial for clinicians and respiratory pharmacologists managing drug-induced asthma.

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