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A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish
Zhenbo Guo1, Mei Wang, Xueyan Li
1Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding 071002, China. weichao@hbu.edu.cn.
Chemical Communications (Cambridge, England)
|October 27, 2020
Abstract:
A hepatocyte-targeting fluorescent N2H4 probe, GHP, was first designed and synthesized employing N-acetylgalactosamine (GalNAc) as the hepatocyte-targeting group and 3-nitrophthalimide as the recognition moiety. The probe can be used to selectively image N2H4 produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ.
