Related Experiment Video

Updated: Jul 17, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.3K

Comparison of poststroke depression between acute ischemic and hemorrhagic stroke patients

Ya-Ying Zeng1,2, Hao-Ran Cheng1, Lin Cheng1,2

  • 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

International Journal of Geriatric Psychiatry
|October 27, 2020
PubMed

Insights

Post-stroke depression (PSD) is more common in intracerebral hemorrhage (ICH) survivors than acute ischemic stroke (AIS) patients. The risk of PSD is more than double in ICH patients compared to AIS patients.

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Research

Background:

  • Post-stroke depression (PSD) is a common complication affecting approximately one-third of stroke survivors.
  • Understanding the differential prevalence of PSD in various stroke types is crucial for targeted interventions.

Purpose of the Study:

  • This prospective study aimed to compare the prevalence and symptoms of PSD between patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH).

Main Methods:

  • Patients with AIS and ICH were enrolled concurrently.
  • Depression symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17) at 1-month follow-up.
  • PSD diagnosis was based on DSM-IV criteria and HAMD-17 scores (>7).

Main Results:

  • The prevalence of PSD was significantly higher in the ICH group (42.3%) compared to the AIS group (22.9%) (p < 0.001).
  • After adjusting for confounding factors, the odds ratio for PSD was 2.65 (95% CI, 1.34-5.24; p = 0.005) in ICH patients versus AIS patients.
  • Anxiety, loss of interest, insomnia, and fatigue were more frequent depressive symptoms in ICH patients.

Conclusions:

  • Post-stroke depression is more prevalent in patients with intracerebral hemorrhage (ICH) than in those with acute ischemic stroke (AIS).
  • The risk of developing PSD is more than twofold higher for ICH survivors compared to AIS survivors.
Abstract

Keywords:
Hamilton Depression Rating Scaleacute ischemic strokeintracranial hemorrhagepoststroke depressionsymptomatology

More Related Videos

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

10.7K
Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients09:42

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Published on: September 1, 2023

1.8K

Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...