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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Panorama of Gynecologic Cancer in Brazil
Eduardo Paulino1,2, Andreia Cristina de Melo1,2, Agnaldo Lopes Silva-Filho2,3
1Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
JCO Global Oncology
|October 27, 2020
Summary
Gynecologic cancer (GC) incidence decreased for some types in Brazil, but advanced diagnoses and treatment delays persist. Mortality rates remain stable, indicating a need for improved early detection and intervention strategies for women.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Gynecologic cancers (GC) represent a significant health concern for women globally.
- Limited consolidated epidemiological data exists for GC in Brazil.
Purpose of the Study:
- To describe the incidence, morbidity, and mortality trends of gynecologic cancers in Brazil.
- To analyze data for the five most common gynecologic cancers between 2000 and 2017.
Main Methods:
- Utilized governmental data sources to collect incidence, morbidity, and mortality information.
- Analyzed data from 382,932 women diagnosed with cervical, uterine, ovarian, vulvar, or vaginal cancer.
Main Results:
- Decreased incidence rates observed for cervical, ovarian, and vaginal cancers; stable rates for uterine and vulvar cancers.
- High proportions of patients diagnosed with locally advanced or advanced disease across all GC types.
- Significant delays in initiating treatment post-diagnosis were noted for most gynecologic cancers.
Conclusions:
- Brazilian patients are diagnosed at later stages of gynecologic cancer compared to international benchmarks.
- Delays in diagnosis-to-treatment contribute to unfavorable outcomes.
- Despite screening and treatment advancements, satisfactory reductions in gynecologic cancer mortality have not been achieved in Brazil.
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