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Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
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Q-PINE: A quick to implant peripheral intraneural electrode.

Ivo Strauss1,2, Thomas Niederhoffer1,2, Alice Giannotti1,2

  • 1The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.

Journal of Neural Engineering
|October 27, 2020
PubMed
Summary

A new method using hollow microneedles significantly reduces surgical time for implanting intraneural electrodes, enabling better sensory feedback for amputees. This approach enhances neural selectivity and electrochemical properties for improved prosthetic control.

Keywords:
PEDOTintraneural electrodeplatinum-iridiumquick to implantselectivity index

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Intraneural electrodes offer sensory feedback for amputees but are challenging and time-consuming to implant.
  • Current implantation requires specialized surgical training, limiting widespread adoption.
  • A need exists for faster, more selective electrode implantation techniques.

Purpose of the Study:

  • To develop a novel peripheral intraneural electrode and insertion mechanism.
  • To drastically reduce overall implantation time.
  • To achieve high neural selectivity for improved prosthetic functionality.

Main Methods:

  • Developed a novel insertion method using hollow microneedles for simultaneous implantation of up to 14 active sites.
  • Utilized Pt/Ir microwires coated with poly-3,4-ethylenedioxythiophene (PEDOT) to enhance electrochemical properties.
  • Evaluated Q-PINE system performance through in vitro and in vivo characterization in pig sciatic nerves, assessing implantation time and neural selectivity.

Main Results:

  • Overall implantation time reduced by 40.3 minutes compared to previous methods.
  • Insertion time for 12 electrodes averaged 6.7 minutes.
  • PEDOT coating improved electrochemical parameters, with an average impedance of 1.7 kΩ and a maximum charge level of 76.2 nC per active site.

Conclusions:

  • The novel Q-PINE system significantly reduces implantation time and complexity.
  • Achieved selective stimulation of multiple muscles (46% of sites), indicating high neural selectivity.
  • Histological analysis confirmed successful nerve and fascicle penetration, validating the electrode's efficacy.