Preterm prelabor rupture of membranes management in Switzerland: a national survey

To gain an overview of the current management of patients with preterm prelabor rupture of membranes (PPROM) in Swiss maternity hospitals.

We conducted a survey among all maternity hospitals in Switzerland from January to December 2018, irrespective of their annual birth rate and level of complexity. The survey consisted of an 11-item questionnaire, which was developed to retrieve information relevant to different areas of PPROM management.

Of 64 questionnaires distributed by email, 36 (56.3%) centers responded to the survey. Up to 12 different antibiotic regimens were reported. Among these, 91.7% included a beta-lactam, with amoxicillin as the preferred agent (55.6%). Combined antibiotic schemes were used in 30.6% of hospitals. All centers considered the use of corticosteroids for fetal lung maturity if PPROM occurred before 34 weeks, although 36.1% would consider their use until 37 weeks' gestation in the presence of an increased risk of neonatal respiratory distress syndrome. Maternity hospitals who accept deliveries at any gestational age usually used magnesium sulfate as fetal neuroprotection when delivering babies <32 weeks, with the exception of two hospitals where it was either not used or only indicated if maternal preeclampsia was present. Concerning the time to delivery, 58.3% centers tended to wait until 37 weeks' gestation, while the others considered that it was not necessary to go beyond 34 weeks.

Our survey shows that the current management of PPROM in Switzerland appears to be mostly in line with international recommendations. However, some heterogeneity exists, thus reflecting a lack of international consensus across guidelines, together with the absence of national Swiss guidelines, and this needs to be addressed to ensure high quality care for all patients and neonates.