Related Experiment Video
Updated: Dec 3, 2025
11:03
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
Published on: December 4, 2017
8.9K
A hidden integral structure endows absolute concentration robust systems with resilience to dynamical concentration
Daniele Cappelletti1, Ankit Gupta1, Mustafa Khammash1
1Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26 4058 Basel, Switzerland.
Journal of the Royal Society, Interface
|October 28, 2020
Summary
Biochemical systems exhibiting absolute concentration robustness (ACR) possess an internal integral structure, enhancing their stability. This structure allows for greater disturbance rejection and robust perfect adaptation, even when interconnected with other systems.
Area of Science:
- Biochemistry
- Systems Biology
- Chemical Kinetics
Background:
- Absolute concentration robustness (ACR) describes biochemical systems maintaining stable expression levels regardless of external changes.
- ACR is crucial for predictable behavior in gene regulatory and signaling networks.
- Previous studies identified specific classes of ACR systems but did not fully elucidate their underlying mechanisms.
Purpose of the Study:
- To mathematically prove the existence of an internal integral structure within a known class of ACR systems.
- To demonstrate how this integral structure enhances system robustness and adaptability.
- To explore the implications of this structure for designing modular biological circuits.
Main Methods:
- Mathematical analysis of biochemical reaction networks.
- Derivation of theoretical properties of ACR systems.
- Investigation of system behavior under various perturbations and interconnections.
Main Results:
- A well-known class of ACR systems possesses an inherent integral structure.
- This structure provides enhanced robustness, rejecting a wider range of disturbances than previously understood.
- Robust perfect adaptation is achieved, maintaining stable expression levels.
- The robustness and adaptability are preserved when ACR systems are interconnected with other networks.
Conclusions:
- The identified integral structure is key to the enhanced robustness of ACR systems.
- This finding facilitates the design of 'insulator' devices for buffering downstream effects in synthetic biology.
- The modular design principles are advanced, enabling more predictable and reliable biological circuit construction.
More Related Videos
Related Concept Videos
02:27Le Chatelier's Principle: Changing Concentration
64.2K
A system at equilibrium is in a state of dynamic balance, with forward and reverse reactions taking place at equal rates. If an equilibrium system is subjected to a change in conditions that affects these reaction rates differently (a stress), then the rates are no longer equal and the system is not at equilibrium. The system will subsequently experience a net reaction in the direction of a greater rate (a shift) that will re-establish the equilibrium. This phenomenon is summarized by Le...
64.2K
01:24Stress Concentrations
518
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
518
01:13Stress Concentrations
467
The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress...
The stress...
467
01:26Constraints and Statical Determinacy
861
In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
861
01:24BIBO stability of continuous and discrete -time systems
780
System stability is a fundamental concept in signal processing, often assessed using convolution. For a system to be considered bounded-input bounded-output (BIBO) stable, any bounded input signal must produce a bounded output signal. A bounded input signal is one where the modulus does not exceed a certain constant at any point in time.
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
780
01:16Non-equilibrium in the Cell
5.1K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
5.1K