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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A)

Nobuyuki Maruyama1, Masato Umikawa2, Hirofumi Matsumoto3

  • 1Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.

Anticancer Research
|October 28, 2020
PubMed
Abstract

Insights

MicroRNA-935 (miR-935) acts as a tumor suppressor in oral squamous cell carcinoma (OSCC) by inhibiting malignancy. This finding suggests miR-935 as a potential therapeutic candidate for OSCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Oral squamous cell carcinoma (OSCC) presents a significant challenge due to its poor prognosis.
  • Novel therapeutic strategies are urgently required to improve patient outcomes.
  • MicroRNAs (miRs) are emerging as promising therapeutic targets for various carcinomas.

Purpose of the Study:

  • To identify novel microRNAs (miRs) implicated in oral squamous cell carcinoma (OSCC) malignancy.
  • To explore the potential of these miRs as therapeutic agents for OSCC.

Main Methods:

  • Utilized miR microarray analysis on OSCC cell lines to identify modulated miRs.
  • Investigated the functional role of identified miRs in OSCC cell behavior.

Main Results:

  • miR-935 and miR-509-3p were found to be downregulated in OSCC cell lines and patient tissues.
  • Overexpression of miR-935 in HSC-3-M3 cells suppressed proliferation, migration, and invasion, while increasing apoptosis.
  • Identified inositol polyphosphate-4-phosphatase type I A (INPP4A) as a direct target gene regulated by miR-935.

Conclusions:

  • miR-935 demonstrates tumor-suppressive activity in OSCC by inhibiting malignancy through INPP4A induction.
  • miR-935 represents a potential novel therapeutic candidate for the treatment of oral squamous cell carcinoma.
Keywords:
INPP4AMicroarraymiR-935microRNAoral squamous cell carcinoma

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