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Melatonin Exerts Anticancer Effects in Human Tongue Squamous Cell Carcinoma Cells by Promoting Autophagy

Eui-Suk Sung1, Joo-Young Kim2, Yong Tae Ahn3

  • 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Anticancer Research
|October 28, 2020
PubMed
Abstract

Insights

Melatonin significantly reduced head and neck squamous cell carcinoma (HNSCC) cell viability and metastasis. This study shows melatonin induces autophagy, suggesting its potential as an anticancer agent for tongue cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Head and neck squamous cell carcinoma (HNSCC) has a high global prevalence and poor prognosis.
  • Investigating novel therapeutic strategies for HNSCC is crucial.

Purpose of the Study:

  • To investigate the anticancer effects of melatonin on human tongue squamous cell carcinoma (SCC-25) cells.
  • To elucidate the underlying mechanisms of melatonin's action, focusing on autophagy.

Main Methods:

  • Cell viability was assessed using MTT assays.
  • Cell migration and invasion were evaluated through wound healing and Transwell assays.
  • Autophagy markers (LC-3B, Beclin-1) were quantified via Western blot analysis.

Main Results:

  • Melatonin treatment significantly inhibited SCC-25 cell viability and colony formation.
  • Melatonin impaired SCC-25 cell migration and invasion capabilities.
  • Melatonin increased the expression of autophagy markers, indicating induced autophagy in SCC-25 cells.

Conclusions:

  • Melatonin demonstrates significant anticancer effects against human tongue squamous cell carcinoma cells.
  • Melatonin-induced autophagy plays a role in its cytotoxic effects.
  • Melatonin holds promise as a potential therapeutic agent for tongue HNSCC.
Keywords:
MTTMelatoninapoptosisautophagyinvasionmigrationtongue squamous cell carcinoma

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