Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

BCOR-CCNB3 fusion-positive sarcoma treated with chemotherapy and carbon-ion radiotherapy: a case report of long-term disease control of a cervical spine case with a 12-year follow-up.

Frontiers in oncology·2026

Same author

Carbon-Ion Radiation Therapy as Nonsurgical Treatment for Early-Stage Breast Cancer: 5-Year Results From the Phase 2 Part of the First Prospective Clinical Trial.

International journal of radiation oncology, biology, physics·2026

Same author

Selection of Radiological Physics and Technology Awards 2025.

Radiological physics and technology·2026

Same author

Local control of locally advanced uterine sarcoma achieved by cervical brachytherapy with gel spacer following cyclic hypofractionated radiation therapy (QUAD shot) in a patient who refused surgery.

BJR case reports·2026

Same author

Impact of the locking function of hybrid inverse planning optimization on the treatment plan quality of intracavitary/interstitial brachytherapy for locally advanced cervical cancer.

Radiological physics and technology·2026

Same author

Robustness of LET<sub>d</sub>-optimized multi-ion therapy against range and setup uncertainties: evaluation and enhancement with carbon-, oxygen-, and neon-ion beams.

Physics in medicine and biology·2026

Search research articles

Related Experiment Video

Updated: Dec 3, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Unresectable Chondrosarcomas Treated With Carbon Ion Radiotherapy: Relationship Between Dose-averaged Linear Energy

Shinnosuke Matsumoto¹, Sung Hyun Lee², Reiko Imai³

¹Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan matsumoto.shinnosuke@qst.go.jp.

Anticancer Research

|October 28, 2020

Summary

Higher linear energy transfer (LET) in carbon-ion radiotherapy (CIRT) improves local control for chondrosarcoma. Effective minimum LETd exceeding 40 keV/μm prevented recurrence in patients with unresectable tumors.

Keywords:

Radiotherapy chondrosarcoma linear energy transfer sarcoma

More Related Videos

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Related Experiment Videos

Last Updated: Dec 3, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Area of Science:

Radiation Oncology
Medical Physics
Skeletal Oncology

Background:

Chondrosarcoma local control with carbon-ion radiotherapy (CIRT) declines with increasing tumor size.
Intra-tumoral linear energy transfer (LET) distribution may influence treatment outcomes.
Understanding LET's role is crucial for optimizing CIRT in chondrosarcoma.

Purpose of the Study:

To investigate the association between intra-tumoral LET distribution and local recurrence in chondrosarcoma patients treated with CIRT.
To determine if specific LET thresholds correlate with improved local tumor control.

Main Methods:

Retrospective analysis of 30 patients with grade 2 chondrosarcoma treated with CIRT.
Calculation of dose-averaged LET (LETd) distribution within the planning tumor volume (PTV) using treatment planning systems.
Evaluation of the relationship between LETd distribution and local control rates.

Main Results:

Mean LETd in the PTV did not differ significantly between recurrent and non-recurrent cases.
No local recurrence was observed when the effective minimum LETd within the PTV exceeded 40 keV/μm.
This suggests a potential protective threshold for local control.

Conclusions:

LETd distribution within the PTV is a significant factor in achieving local control for chondrosarcomas treated with CIRT.
Higher LETd ion beam therapy may enhance local control rates for unresectable chondrosarcomas.
Targeting specific LETd levels could be a strategy to improve CIRT efficacy.