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Published on: March 27, 2018
Gender difference in long- and short-term outcomes of off-pump coronary endarterectomy
Feridoun Sabzi1, Atefeh Asadmobini1
1Cardiovascular Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Insights
Gender does not significantly impact outcomes for off-pump coronary artery bypass grafting (CABG) and coronary endarterectomy (CE). However, women may face a slightly higher risk, warranting further investigation into gender-specific cardiac surgery results.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery Outcomes
- Gender Differences in Medicine
Background:
- The effectiveness of different coronary artery disease treatments based on gender is debated.
- Off-pump coronary endarterectomy (CE) is a surgical option for diffused coronary artery diseases.
- This study investigates gender's impact on CE outcomes.
Purpose of the Study:
- To evaluate the effect of gender on short- and long-term outcomes of off-pump coronary endarterectomy (CE).
- To compare outcomes between male and female patients undergoing CABG and CABG + CE.
Main Methods:
- Single-center retrospective study of patients undergoing coronary artery bypass graft (CABG).
- Patients divided into CABG and CABG + CE groups, stratified by gender.
- Kaplan-Meier analysis and Cox regression used to assess survival and predictors.
Main Results:
- No significant differences in postoperative outcomes or hospital mortality between genders.
- No significant difference in 5-year cardiac mortality between males and females.
- Diseased vessel characteristics were similar between genders.
Conclusions:
- Off-pump CABG and CE show no significant gender-based differences in short- and long-term outcomes.
- Women may have a slightly elevated risk, suggesting a need for further research.
- Findings contribute to understanding gender's role in surgical treatment for coronary artery disease.
Background:
The role of gender in the selection of the most effective method for treatment of patients with diffused coronary artery diseases remains a matter of debate. This study thus evaluated the effect of gender on long- and short-term outcomes of off-pump coronary endarterectomy (CE).
Methods:
This was a single-center retrospective study of patients who had undergone coronary artery bypass graft (CABG). The patients were divided into two groups, the CABG and the CABG + CE group, and further stratified into male and female. Long-term survival for each group was estimated by Kaplan-Meier analysis with log-rank testing. In addition, Cox regression analyses of each gender were also carried out to identify the predictors of the primary and secondary endpoints.
Results:
Overall, 25.8% of the patients were female. Diseased vessels were not statistically different in the two groups - men and women. There was no significant difference in postoperative outcomes between males and females in the CABG and CABG + CE groups. There was no significant difference in hospital mortality in the two groups between males and females. Kaplan-Meier curves show that there was no significant difference in the 5-year cardiac mortality between males and females belonging to the CABG and CABG + CE groups.
Conclusion:
The results of this study show that there was no significant difference in the short- and long-term outcomes of off-pump CABG and CE in both genders although women tend to carry a greater risk.
