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The future of microfluidics in immune checkpoint blockade
Jonathan Briones1, Wilfred Espulgar1, Shohei Koyama2
1Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
Cancer Gene Therapy
|October 28, 2020
Summary
Microfluidic technology advances immune checkpoint therapy research by enabling personalized medicine and antibody discovery. Overcoming current challenges will shift this technology towards clinical applications for improved immunotherapy efficacy.
Area of Science:
- Biomedical Engineering
- Immunology
- Oncology
Background:
- Microfluidic techniques are advancing the study of sensitivities to immune checkpoint therapy.
- These technologies aid in determining patient response to antibody treatments and personalized medicine design.
- Microfluidics supports immunologic, genomic, and transcriptomic analyses to enhance immunotherapy efficacy.
Purpose of the Study:
- To review advancements in microfluidic technologies for immune checkpoint blockade (ICB) research.
- To explore the potential of microfluidics in shifting from proof-of-principle to clinical application.
- To highlight the role of microfluidics in improving immunotherapy efficacy and coverage.
Main Methods:
- Review of recent literature on microfluidic applications in immunotherapy research.
- Analysis of microfluidic functions in immunologic, genomic, and transcriptomic analysis.
- Examination of challenges and future directions for clinical translation.
Main Results:
- Microfluidics enables sensitive analysis of immune checkpoint therapy response.
- The technology facilitates antibody discovery and personalized medicine development.
- Current microfluidic approaches offer potential for improved immunotherapy, but challenges remain.
Conclusions:
- Microfluidic technologies show significant promise for advancing immune checkpoint blockade research.
- Further development is needed to overcome technical challenges and facilitate clinical adoption.
- Microfluidics is poised to play a crucial role in the future of personalized immunotherapy.
