Related Experiment Video
Updated: Dec 3, 2025

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells
Esra Aydemİr Çoban1, Didem Tecİmel1,2, Ezgi KaŞikci1,3
1Department of Genetics and Bioengineering, Engineering Faculty, Yeditepe University, İstanbul Turkey.
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.
Related Concept Videos
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Cancer Cell Migration through Invadopodia
Structure of Cadherins
Adherens Junctions
Adherens Junctions are Dynamic
Catenins
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

