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Decoding Aging: Understanding the Complex Relationship among Aging, Free Radicals, and GSH

María E López-Navarro1, Mariana Jarquín-Martínez1, Luis A Sánchez-Labastida1

  • 1Departamento de Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340, Mexico.

Oxidative Medicine and Cellular Longevity
|October 28, 2020
PubMed
Summary

Aging decreases reduced glutathione (GSH) and increases free radicals (FRs), disrupting cellular redox homeostasis. Electrophilic maleimides like 3,5-DMB exacerbate FR levels, highlighting age-related molecular changes.

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