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Effects of Cystatin C on Cognitive Impairment in Older Chinese Adults
Zhizhen Cui1, Guizhen Cao1, Youyi Wang1
1Department of Child Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, 12582Soochow University, Suzhou, People's Republic of China.
Objective:
To find a suitable dividing value to classify cystatin C and evaluate the association between cognition and levels of cystatin C.
Methods:
Using data from the China Health and Retirement Longitudinal Study, We conducted a longitudinal analysis of a prospective cohort of 6,869 middle-aged and older Chinese without cognitive impairment at baseline. Levels of cystatin C were categorized into 2 groups by method of decision tree. Logistic regression models evaluated whether cystatin C was related to cognitive impairment.
Results:
Respondents were categorized as lower levels of cystatin C and higher levels of cystatin C, cut-point was 1.11 mg/L. Higher levels of cystatin C was associated with the odds of cognitive impairment (OR, 1.56; 95% CI, 1.10-2.22) after multivariable adjustment. Respondents with higher levels of cystatin C had worse cognition scores.
Conclusions:
We found a suitable dividing value of cystatin C in middle-aged and older Chinese.
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