Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.7K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.7K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.4K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.4K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.3K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of angiotensin receptor-neprilysin inhibitor therapy on urinary C-peptide measurements: A potential pitfall in the β-cell function assessment.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

In Vitro Assessment of Osteogenic Modulation and Molecular Responses Induced by Contemporary Endodontic Sealers in MC3T3-E1 Pre-Osteoblasts.

Dentistry journal·2026
Same author

An Orbital Abscess Caused by Fusobacterium nucleatum Mimicking Tolosa-Hunt Syndrome.

Cureus·2026
Same author

Immunohistological Characterization of Minced Dental Pulp Transplant in an Ectopic Mouse Model.

Journal of endodontics·2025
Same author

Occurrence of Motor Complications and Gait Problems After Introduction of Medical Treatment in Parkinson's Disease.

Parkinson's disease·2025
Same author

Heel-Elevation Effects on Sit-to-Stand Movement in Patients with Parkinson's Disease-A Randomized Crossover Study.

NeuroRehabilitation·2025

Related Experiment Video

Updated: Dec 3, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.0K

Identification of a pre-possible multiple system atrophy phase.

Yasushi Osaki1, Yukari Morita1, Yuka Miyamoto1

  • 1Department of Neurology, Kochi Medical School Hospital, Nankoku, Japan.

Acta Neurologica Scandinavica
|October 28, 2020
PubMed
Summary

A pre-possible phase for multiple system atrophy (MSA) exists, identified by specific symptoms and MRI findings. Early diagnosis of MSA can be improved by recognizing these early indicators.

Keywords:
clinical diagnosismultiple system atrophyorthostatic hypotensionurinary disturbance

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.8K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.2K

Related Experiment Videos

Last Updated: Dec 3, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.0K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.8K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.2K

Area of Science:

  • Neurology
  • Neurodegenerative Diseases

Background:

  • Multiple system atrophy (MSA) diagnosis is often delayed until established criteria are met.
  • A potential pre-diagnostic phase, preceding formal criteria, may offer opportunities for earlier identification.

Purpose of the Study:

  • To identify the characteristics of a pre-possible multiple system atrophy (MSA) phase.
  • To explore methods for earlier diagnosis of MSA.

Main Methods:

  • Retrospective review of 52 patients with diagnosed MSA.
  • Analysis of 430 patients with parkinsonism, ataxia, or autonomic failure.
  • Evaluation of presenting symptoms and diagnostic indicators.

Main Results:

  • A pre-possible MSA phase was identified in 48 patients (35 with MSA, 13 with other diagnoses).
  • Autonomic features presented first in 16 patients during this phase.
  • MRI findings (putaminal, cerebellar, brainstem atrophy) and new/increased snoring showed high positive predictive values for MSA.

Conclusions:

  • The existence of a pre-possible MSA phase is confirmed.
  • Earlier MSA diagnosis relies on sensitive autonomic testing and specific MRI/snoring indicators during this early phase.