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Association Between Human Papilloma Virus Infection and Malignant Sinonasal Inverted Papilloma

Ronghua Ding1, Qiaorong Sun2, Yong Wang1

  • 1Department of Otorhinolaryngology, Taizhou Second People's Hospital of Jiangsu Province, Taizhou, China.

The Laryngoscope
|October 28, 2020
PubMed
Abstract

Insights

Human papillomavirus (HPV) types 16, 18, and their combinations significantly increase the risk of malignant sinonasal inverted papilloma (SNIP). However, HPV types 6 and 11 do not show a significant association with malignant SNIP development.

Area of Science:

  • Otolaryngology
  • Oncology
  • Virology

Background:

  • Sinonasal inverted papilloma (SNIP) is a benign tumor with a potential for malignant transformation.
  • Human papillomavirus (HPV) infection is implicated in the pathogenesis of various head and neck cancers.
  • The specific role of different HPV types in the malignant progression of SNIP requires further clarification.

Purpose of the Study:

  • To systematically review and meta-analyze the association between specific HPV types and the risk of malignant transformation in SNIP.
  • To quantify the risk of malignant SNIP based on HPV infection status.

Main Methods:

  • A systematic literature search was conducted across PubMed, EmBase, and Web of Science databases.
  • Molecular epidemiological studies reporting HPV types and malignant SNIP risk were included.
  • Quantitative meta-analysis was performed to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).

Main Results:

  • Twenty-six studies comprising 900 SNIP patients were analyzed.
  • HPV types 16, 18, HPV 11/16, and HPV 16/18 infections were significantly associated with an increased risk of malignant SNIP (ORs ranging from 7.95 to 24.34).
  • HPV types 6, 11, and HPV 6/11 infections did not demonstrate a statistically significant association with malignant SNIP risk.

Conclusions:

  • HPV types 16 and 18 are key oncogenic drivers associated with malignant transformation of SNIP.
  • Patients with SNIP infected by HPV types 16, 18, 11/16, or 16/18 face a substantially elevated risk of developing malignant disease.
  • Further research may focus on HPV-targeted therapies for SNIP management.
Keywords:
Riskinfectionmeta-analysissinonasal inverted papilloma

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