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Updated: Dec 3, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Subclinical hypothyroidism: to treat or not to treat?
Robin P Peeters1, Juan P Brito2
1Department of Internal Medicine, Erasmus MC Academic Center for Thyroid Disease, Erasmus MC, Rotterdam, The Netherlands.
Abstract:
There is controversy on the treatment of subclinical hypothyroidism (SCH). While a number of guidelines from professional societies recommend treatment of SCH based on TSH levels, age, and presence of comorbidities, a recent guideline issued a recommendation against thyroid hormone treatment in adults with SCH. In this debate article, we explore this controversy by presenting two points of view about SCH and its treatment. Treatment of patients who are pregnant or trying to become pregnant will not be discussed.
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