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CMIP SNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy

Ling Pan1, Yun-Hua Liao1, Man-Qiu Mo1

  • 1Department of Nephrology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.

Bioscience Reports
|October 28, 2020
PubMed

Insights

This study reveals that specific gene variations in the c-Maf-inducing protein (CMIP) are linked to dyslipidaemia and kidney damage in IgA nephropathy (IgAN) patients. These CMIP single-nucleotide polymorphisms (SNPs) and haplotypes are associated with lipid profiles and disease severity.

Area of Science:

  • Genetics
  • Nephrology
  • Biochemistry

Background:

  • IgA nephropathy (IgAN) is a common glomerular disease with variable clinical outcomes.
  • The interplay between serum lipid profiles, clinicopathological features, and specific gene polymorphisms in IgAN remains incompletely understood.
  • c-Maf-inducing protein (CMIP) gene polymorphisms have not been extensively studied in relation to IgAN complications.

Purpose of the Study:

  • To investigate the association between CMIP single-nucleotide polymorphisms (SNPs) and the occurrence of dyslipidaemia in IgAN patients.
  • To examine the correlation of CMIP SNPs with the clinicopathological features of IgAN.
  • To explore the relationship between CMIP haplotypes and dyslipidaemia in the IgAN cohort.

Main Methods:

  • Genotyping of CMIP rs2925979 and CMIP rs16955379 SNPs was performed using PCR and direct sequencing in 543 IgAN patients.
  • Clinical and pathological data, including lipid profiles, blood pressure, renal function markers, and kidney histology, were collected and analyzed.
  • Statistical analyses, including multivariate linear regression and haplotype analysis, were employed to assess associations.

Main Results:

  • Dyslipidaemia was present in 51.7% of IgAN patients and was associated with poorer clinicopathological features (e.g., higher blood pressure, lower eGFR).
  • Specific CMIP SNPs (rs16955379 and rs2925979) and their common haplotypes (e.g., rs2925979G-rs16955379T) showed significant correlations with lipid profiles (total cholesterol, LDL, HDL, ApoB) and dyslipidaemia status.
  • The frequencies of CMIP SNP haplotypes differed significantly between IgAN patients with and without dyslipidaemia.

Conclusions:

  • Dyslipidaemia is a frequent complication in IgAN, exacerbating clinicopathological damage.
  • CMIP gene polymorphisms and their haplotypes are significantly associated with the development of dyslipidaemia in IgAN patients.
  • These findings suggest that CMIP SNPs may serve as potential genetic markers for dyslipidaemia and disease severity in IgAN.
Keywords:
IgA nephropathyc-Maf-inducing protein geneclinicopathologic featureslipidssingle nucleotide polymorphisms

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