Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

12.0K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
12.0K
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

621
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
621
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

161
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
161

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase linear encoding in multi-line transmit imaging: Towards crosstalk artifact removal.

Ultrasonics·2026
Same author

Optical Tracking for Freehand Swept Synthetic Aperture Imaging.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same author

Noninvasive Hemodynamic Assessment by a Sensor Patch: The PATCHWRK (PortAble TeCHnology for Wireless caRdiomyopathy tracKing) Study.

JACC. Advances·2025
Same author

Clutter-Generating Phantom Material. Part I: Development of a Tunable, Acoustic Clutter-Generating Layer for Use With Ultrasound Tissue-Mimicking Phantoms.

Ultrasound in medicine & biology·2025
Same author

Toward widespread use of virtual trials in medical imaging innovation and regulatory science.

Medical physics·2024
Same author

Optimization of array encoding for ultrasound imaging.

Physics in medicine and biology·2024
Same journal

Theoretical Foundations of the Echo Envelope Statistical Modeling: A Tutorial.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Practical Demonstrations of FR3-Band Thin-Film Lithium Niobate Acoustic Filter Design.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Real-Time Heterogeneous Helical Wave Spectrum Method for Transabdominal Passive Acoustic Mapping.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Cascaded Plane Wave Ultrasound Velocity Vector Imaging: In Vivo Feasibility in Carotid Arteries.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

Quantitative Acoustic Attenuation Scanning Using a Phase-Insensitive Ultrasound Computed Tomography System.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
Same journal

FPGA-Accelerated CNN Reconstruction for Low-Power Sparse-Array Ultrasound Imaging.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2025
See all related articles

Related Experiment Video

Updated: Dec 3, 2025

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.8K

Resolution and Speckle Reduction in Cardiac Imaging.

Nick Bottenus, Melissa LeFevre, Jayne Cleve

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |October 28, 2020
    PubMed
    Summary
    This summary is machine-generated.

    This study examines how to balance image clarity and noise reduction in heart ultrasounds. Researchers used a new focusing method to test different levels of spatial compounding, a technique that averages multiple views to smooth out grainy noise. While mathematical models favored high-level smoothing, human experts preferred lower levels for actual diagnostic tasks.

    Keywords:
    ultrasound noise reductionendocardial border detectabilitysynthetic aperture focusingdiagnostic image quality

    Frequently Asked Questions

    More Related Videos

    Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
    09:05

    Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

    Published on: October 20, 2016

    20.0K
    Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts
    05:58

    Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts

    Published on: March 29, 2024

    1.3K

    Related Experiment Videos

    Last Updated: Dec 3, 2025

    Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
    07:13

    Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

    Published on: December 22, 2023

    1.8K
    Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
    09:05

    Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

    Published on: October 20, 2016

    20.0K
    Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts
    05:58

    Author Spotlight: Customized Light-Sheet Imaging for Investigating Myocardial Structures in Rodent Hearts

    Published on: March 29, 2024

    1.3K

    Area of Science:

    • Medical physics and cardiac ultrasound imaging research
    • Diagnostic imaging and speckle reduction optimization

    Background:

    Clear visualization of heart structures remains a challenge for clinicians assessing ventricular function. Ultrasound images often suffer from grainy interference caused by tiny tissue scatterers. This noise obscures underlying anatomy and complicates accurate diagnostic assessments. Prior research has shown that smoothing techniques can mitigate this interference. However, these methods frequently degrade spatial detail during the process. That uncertainty drove the need to quantify the balance between clarity and noise suppression. No prior work had resolved the discrepancy between automated metrics and human preference in this context. This study addresses the gap by evaluating how specific compounding levels impact diagnostic utility.

    Purpose Of The Study:

    The aim of this study is to evaluate the tradeoff between resolution and noise reduction in cardiac ultrasound imaging. Researchers specifically investigate how spatial compounding influences diagnostic value. This gap motivated the team to quantify the relationship between texture suppression and image detail. The study seeks to determine if mathematical improvements in image quality correlate with clinical utility. Investigators also aim to compare automated contrast metrics with expert human assessments. They propose that understanding this balance is vital for optimizing diagnostic protocols. The project addresses the lack of consensus on the ideal level of compounding for heart imaging. This work provides a framework for assessing how different processing conditions impact the detectability of cardiac structures.

    Main Methods:

    Review approach involved evaluating the tradeoff between resolution and noise reduction using an imaging phantom. The team employed a synthetic aperture focusing technique to process harmonic backscattered data. This approach allowed for the decomposition of signals into spatial frequency components for transmit and receive compounding. Investigators performed cardiac ultrasounds on 25 subjects to gather clinical data. They included 18 subjects in the final qualitative and quantitative analysis. Three expert reviewers ranked four distinct compounding conditions for various diagnostic tasks. The researchers calculated the generalized contrast-to-noise ratio to quantify detectability improvements. This methodology enabled a direct comparison between objective metrics and subjective clinical preferences.

    Main Results:

    Key findings from the literature indicate that spatial compounding consistently improved endocardial border detectability according to the generalized contrast-to-noise ratio. More aggressive compounding provided further quantitative gains in ten out of 18 cases. Despite these objective improvements, expert reviewers preferred low-level compounding in 77.9% of diagnostic tasks. The remaining 21.2% of cases favored either no compounding or medium-level settings. These results demonstrate a clear conflict between automated quality metrics and human expert judgment. The phantom data confirmed that increased compounding levels successfully reduced texture but simultaneously degraded lateral resolution. The study highlights that high levels of compounding are not always optimal for clinical utility. These findings suggest that human preference prioritizes detail over the noise reduction suggested by mathematical models.

    Conclusions:

    The authors propose that spatial compounding enhances the visibility of the endocardial border across all tested scenarios. Synthesis and implications suggest that while mathematical contrast metrics favor high-level smoothing, human experts prioritize preserving detail. The researchers indicate that low-level compounding is generally preferred for clinical diagnostic tasks. This finding highlights a divergence between objective image quality scores and subjective expert assessment. The study implies that automated metrics may not fully capture the requirements of clinical interpretation. The team suggests that these results generalize to other noise reduction strategies in medical imaging. The data confirm that aggressive smoothing can sometimes hinder rather than help diagnostic performance. Future clinical protocols should balance quantitative improvements with the practical needs of human readers.

    The researchers propose that spatial compounding reduces grainy interference by averaging decorrelated patterns from multiple subaperture positions. This mechanism improves endocardial border visibility, though it inherently sacrifices lateral resolution due to the reduction in active aperture size.

    The team utilized a novel synthetic aperture focusing technique to decompose harmonic backscattered data into aperture-domain spatial frequency components. This tool enables the simultaneous evaluation of transmit and receive compounding across various conditions from a single acquisition.

    The authors note that the tradeoff between resolution and noise reduction is necessary because spatial compounding requires averaging multiple views. This process physically limits the active aperture size, which directly dictates the lateral resolution of the resulting ultrasound image.

    The researchers used harmonic backscattered data to perform both qualitative and quantitative analyses. This data type allowed them to compare objective generalized contrast-to-noise ratios against subjective rankings provided by three expert reviewers.

    The study measured the generalized contrast-to-noise ratio to assess lesion detectability. They compared this quantitative metric against the qualitative rankings of four compounding conditions—none, low, medium, and high—provided by human experts.

    The authors propose that while quantitative metrics suggest high levels of compounding are beneficial, human experts prefer low levels in 77.9% of cases. This suggests that clinical diagnostic utility does not always align with purely mathematical image quality improvements.