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Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

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Oral ciprofloxacin as prophylaxis in transurethral resection of the prostate

D A Murdoch1, D F Badenoch, E R Gatchalian

  • 1Department of Medical Microbiology, London Hospital.

British Journal of Urology
|August 1, 1987
PubMed

Insights

Ciprofloxacin prophylaxis effectively reduced post-operative infections and complications in patients undergoing transurethral resection of the prostate. This oral antibiotic demonstrated good tolerability with no significant side effects observed.

Area of Science:

  • Pharmacology and Urology
  • Infectious Disease Prevention

Background:

  • Transurethral resection of the prostate (TURP) is associated with a significant risk of post-operative infections.
  • Effective prophylactic strategies are crucial to minimize morbidity and improve patient outcomes following TURP.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral ciprofloxacin as a prophylactic agent for TURP.
  • To assess the impact of ciprofloxacin prophylaxis on post-operative infection rates and hospital stay.

Main Methods:

  • A randomized controlled trial was conducted.
  • Participants received a 3-day course of perioperative ciprofloxacin (250 mg twice daily).
  • Infection rates, hospital stay, and complications were monitored.

Main Results:

  • Perioperative ciprofloxacin significantly reduced the post-operative infection rate.
  • A notable decrease in post-operative hospital stay was observed.
  • The frequency of infective complications was also reduced with ciprofloxacin use.

Conclusions:

  • Oral ciprofloxacin is an effective prophylactic agent for transurethral resection of the prostate.
  • Ciprofloxacin prophylaxis is well-tolerated, with no significant adverse haematological or biochemical effects.
  • This regimen offers a safe and beneficial approach to preventing infections after TURP.

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