Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene fusions in non-small cell lung carcinoma (NSCLC): Expert perspectives and practical considerations for routine testing.

Critical reviews in oncology/hematology·2026
Same author

New biomarkers for antibody-drug conjugates in lung cancer the pathologist's perspective.

Lung cancer (Amsterdam, Netherlands)·2026
Same author

Limited predictive value of PD-L1 TPS for pathological response in NSCLC is not attributable to interobserver variability.

Lung cancer (Amsterdam, Netherlands)·2026
Same author

GLP-1 receptor agonist therapy before bariatric surgery: Effects on weight loss and body composition in clinical practice.

Obesity research & clinical practice·2026
Same author

Modelling and Implementation of a Precision-Oncology Data-Integration Platform for Real-Word Molecular Tumor Borad Decision-Making.

Studies in health technology and informatics·2026
Same author

Testosterone Therapy in Women: A Literature Review of Clinical Indications, Dosing, Routes of Administration, and Safety.

Cureus·2026

Related Experiment Video

Updated: Dec 3, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.6K

Pan-TRK Immunohistochemistry: An Example-Based Practical Approach to Efficiently Identify Patients With NTRK Fusion

Esther Conde1, Susana Hernandez2, Elena Sanchez2

  • 1From Pathology and Laboratory of Therapeutic Targets, Hospital Universitario HM Sanchinarro, HMHospitales, CIBERONC, Madrid, Spain (Conde, Lopez-Rios).

Archives of Pathology & Laboratory Medicine
|October 28, 2020
PubMed
Summary
This summary is machine-generated.

Identifying NTRK fusions is crucial for targeted cancer therapy. This update provides guidance on using pan-TRK immunohistochemistry (IHC) to improve the detection of these challenging genetic alterations in various tumors.

More Related Videos

A Next-generation Tissue Microarray ngTMA Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray ngTMA Protocol for Biomarker Studies

Published on: September 23, 2014

24.4K
Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
10:04

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Published on: March 13, 2018

12.4K

Related Experiment Videos

Last Updated: Dec 3, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.6K
A Next-generation Tissue Microarray ngTMA Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray ngTMA Protocol for Biomarker Studies

Published on: September 23, 2014

24.4K
Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
10:04

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Published on: March 13, 2018

12.4K

Area of Science:

  • Oncology
  • Pathology
  • Molecular Diagnostics

Background:

  • TRK inhibitors are effective treatments for cancers with NTRK rearrangements.
  • Identifying NTRK fusions is challenging due to their rarity in specific cancer types.
  • Current diagnostic approaches involve a two-step screening and confirmation process.

Purpose of the Study:

  • To offer a practical update on the application of pan-TRK immunohistochemistry (IHC).
  • To illustrate diverse IHC staining patterns across different cancer histologies.

Main Methods:

  • Comprehensive literature review utilizing PubMed.
  • Incorporation of diagnostic and research expertise in pan-TRK IHC.

Main Results:

  • Pan-TRK IHC serves as a valuable screening tool for NTRK fusions.
  • Specific staining patterns can aid in the interpretation of IHC results.
  • Examples across multiple histologies are presented to guide pathologists.

Conclusions:

  • Expertise in pan-TRK IHC is essential for pathologists.
  • A rational approach to detecting NTRK fusions can be implemented.
  • Improved detection facilitates the use of targeted TRK inhibitor therapies.