Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Analytical Chemistry

Background:

• Differential scanning calorimetry (DSC) is crucial for analyzing drug-excipient interactions in drug delivery systems (DDSs).
• Understanding drug complexation within DDSs is vital for optimizing drug efficacy and stability.
• Cyclodextrins, like 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), are common excipients used to enhance drug solubility and delivery.

Purpose of the Study:

• To establish a protocol for studying drug interactions and entrapment efficiency using DSC.
• To investigate the complexation of losartan and irbesartan with 2-HP-β-CD.
• To differentiate between physical mixtures and true complexes of these drugs within the cyclodextrin matrix.

Main Methods:

• Differential scanning calorimetry (DSC) was employed to analyze thermal properties.
• Losartan and irbesartan were physically mixed and complexed with 2-hydroxypropyl-β-cyclodextrin.
• Thermograms of mixtures and complexes were compared to assess drug-excipient interactions.

Main Results:

• Significant differences in thermal scan properties were observed between physical mixtures and complexes.
• DSC thermograms clearly distinguished between the states of losartan and irbesartan when mixed or complexed with 2-HP-β-CD.
• The study confirmed the utility of DSC in characterizing drug states within pharmaceutical formulations.

Conclusions:

• Differential scanning calorimetry is a valuable tool for characterizing drug-excipient interactions in DDSs.
• The protocol effectively differentiates between physical mixtures and complexes of sartans with 2-HP-β-CD.
• DSC provides insights into the state of drug molecules within cyclodextrin-based formulations.