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Related Experiment Video

Updated: Dec 3, 2025

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

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Advances in Human Lung Transplantation.

Aparna C Swaminathan1,2, Jamie L Todd1,2, Scott M Palmer1,2

  • 1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA; email: aparna.swaminathan@duke.edu, jamie.todd@duke.edu, scott.palmer@duke.edu.

Annual Review of Medicine
|October 28, 2020
PubMed
Summary

Lung transplantation offers improved survival for advanced lung disease. Ongoing research aims to better diagnose, prevent, and treat chronic lung allograft dysfunction (CLAD), a key factor limiting long-term transplant success.

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Latent Class Analysis Identifies Pulmonary Function Trajectory Phenotypes in Lung Transplant Recipients with Chronic Allograft Dysfunction.

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Area of Science:

  • Pulmonology
  • Transplant Immunology
  • Immunology

Background:

  • Lung transplantation is a life-saving procedure for end-stage lung disease.
  • Transplant volume has increased, including older and sicker patients, due to organ preservation advances.
  • Post-transplant complications, including primary graft dysfunction, acute rejection, and chronic lung allograft dysfunction (CLAD), are significant challenges.

Purpose of the Study:

  • To review advances in lung transplantation, focusing on complications and outcomes.
  • To highlight the understanding and management of chronic lung allograft dysfunction (CLAD).
  • To discuss ongoing research for improving long-term lung transplant survival.

Main Methods:

  • Review of current literature and clinical practice in lung transplantation.
Keywords:
bronchiolitis obliteransgraft rejectionlung transplantationorgan preservationprimary graft dysfunction

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  • Analysis of diagnostic and mechanistic understanding of post-transplant complications.
  • Exploration of emerging research in CLAD diagnosis, prevention, and treatment.

    • Main Results:

    • Lung transplantation significantly improves survival and quality of life.
    • Chronic Lung Allograft Dysfunction (CLAD) is the primary barrier to long-term survival.
    • Distinguishing CLAD phenotypes (Bronchiolitis Obliterans Syndrome, Restrictive Allograft Syndrome) aids mechanistic understanding.

    Conclusions:

    • Continued advancements in lung transplantation are improving patient outcomes.
    • Further research into CLAD is crucial for enhancing long-term graft survival.
    • Novel strategies for CLAD management are essential for the future of lung transplantation.