Discovery of post-translational modifications in immunometabolism by chemical proteomics
Yanling Zhang1, Wei Qin1, Chu Wang2
1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Abstract:
Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce post-translational modifications (PTMs) on proteins. Understanding the functional implications of these modifications requires precise identification of them from complex biological samples. We herein review recent progress in systematic discovery of immunometabolite PTMs by chemical proteomics.
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